Asclepiades of Samos (Greek: Ἀσκληπιάδης ὁ Σάμιος; born c. 320 BC) was an ancient Greek epigrammatist and lyric poet who flourished around 270 BC. He was a friend of Hedylus and possibly of Theocritus. He may have been honoured by the city of Histiaea in about 263 BC.
Asclepiades was the earliest and most important of the convivial and erotic epigrammists. Only a few of his compositions were intended as actual inscriptions, if any. Other poems sing the praises of those poets whom he especially admired, but the majority of his work that has survived is love songs. It is doubtful whether he is the author of all the epigrams (some 40 in number) which bear his name in the Greek Anthology. He has been credited with creating the metre which bears his name, the Asclepiad metre. The sole source for the known, unlacunaed epigrams of Asclepiades is the Greek Anthology.